Abstract

VARGAS-HERNANDEZ, Jhonny E; CAMACHO-GOMEZ, María P  and  RAMIREZ DE PENA, Doris. Effects of nutrients and bioactive compounds of foods in tissues and cells of human cancer: nutrigenomics approach. rev.fac.med. [online]. 2013, vol.61, n.3, pp.293-300. ISSN 0120-0011.

Summary Cancer is a genetic programming abnormal condition in which the change in genomic sequence may alter the structure, function and expression of proteins that control essential cellular processes such as growth, proliferation, differentiation and apoptosis. Nutrition and cancer research have analyzed the effects of certain nutrients and bioactive food compounds in the development and progression of various cancers. The aim of this research was to review, in the recent scientific information, the effects or interactions of nutrients and bioactive food compounds in tissue and cells of human cancer under a nutrigenomics approach. We did a search of articles published between January 2011 and October 2012 in the Pubmed database, using MeSH terms and "Text Word" relevant to the research objective. This search yielded 250 publications which 33 were selected. In general, the effects and interactions of the nutrients and bioactive compounds selectively induce death and inhibit the growth and proliferation of cancer cells, however, under certain conditions, such effects and interactions may promote carcinogenesis.

Keywords : Neoplasms; diet; nutrigenomics; gene expression.

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