Abstract

RUIZ RADA, Jorge Andrés; FERNANDEZ, Juan Manuel  and  HERNANDEZ VALDIVIESO, Alher Mauricio. Closed loop system prototype for intravenousanesthesia administration. Rev.fac.ing.univ. Antioquia [online]. 2009, n.50, pp.99-110. ISSN 0120-6230.

This paper presents the development of a closed-loop system for intravenous administration. Therefore, several sub-systems have been developed independently. A multi-compartment drug distribution model for the human body, an algorithm for determining the infusion rate of Propofol to achieve the desired anesthesia effect, a communication protocol for sending the infusion rate array to a conventional infusion pump. Finally, a feedback to control the whole system based on a bi-spectral index signal (BIS) as an anesthetic deepness measure. The final result is a useful instrument, similar to commercially available systems, with a friendly interface that can be controlled by the anesthesiologist from a personal computer.

Keywords : system modeling; control systems; intravenous anesthesia; farmaco kinetics; bioinstrumentation.

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