Abstract

MONTEALEGRE ORTIZ, María Camila et al. Helicobacter pylori detection and human Interleukin 1-ß genotyping in Colombian patients affected by gastroduodenal diseases. Rev Col Gastroenterol [online]. 2008, vol.23, n.1, pp.40-44. ISSN 0120-9957.

The aim of this study was to investigate the presence of Helicobacter pylori and interleukin 1-β genotyping (IL-1B -31), to determine the relationship between one polymorphism in the -31 region of interleukin 1-β gene and the severity of the clinical manifestations. Gastric biopsies from 71 patients were submitted to histopathological examination and genotyped by molecular methods (PCR y PCR-RFLP). The results indicated that 97.2% of the patients have alterations in the gastric mucosa, the presence of H. pylori was demonstrated in 44 patients and TT, CT and CC genotypes were detected in 12.7%, 60.6% and 26.8%, respectively. IL-1B genotypes were not associated with the severity of gastric mucosal damage in the studied population.

Keywords : Human interleukin 1-ß; Genotyping; PCR-RFLP; Gastroduodenal diseases; Colombia.

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