Abstract

PEGUERO SANCHEZ-NAVARRO, JULIO  and  GONZALEZ-ANGULO, ANA MARÍA. TRIPLE NEGATIVE BREAST CANCER. rev.fac.med [online]. 2008, vol.16, n.2, pp.192-199. ISSN 0121-5256.

Triple negative breast cancer is a subtype of malignancy that does not express receptors for estrogen, progesterone or HER2NEU. The majority of these tumors form part of the "basal" genetic profile, but the terms are not synonymous or interchangeable. Because of their aggressive biology, they require a multidisciplinary approach. The relation between the BRCA gene and these tumors is still undefined and the subject of growing research. Premenopausal african americans have been identified in the United States as one of the ethnic groups at risk for this type of tumor. This neoplasm is sensitive to conventional chemotherapy but it remains at a high risk of recurrence. Some of the molecular targets include the epithelial growth factor receptors (EGFR), vascular endothelial growth factor (VGEF) and the poliadenosin-diphosphate-polimerase (PARP).

Keywords : breast neoplasm; receptors; estrogen; receptors; progesterone.

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