Abstract

BARRALES CURENO, Hebert Jair  and  RAMIREZ SEPULVEDA, Marco Favio. A review on the production of taxoids anti-cancer of callus and cells of Taxus spp. in cultures in vitro. Rev. colomb. biotecnol [online]. 2013, vol.15, n.2, pp.167-177. ISSN 0123-3475.  https://doi.org/10.15446/rev.colomb.biote.v15n2.41743.

The taxoids are polioxigenated diterpenes from the metabolic pathway of the 2-methyl-erythritol 4-phosphate whose biosynthesis is generated in the plastides. The importance of the taxoides including taxol, in the area of human medicine is very valuable due to the use in oncology, drug used against breast, lung and ovarian cancer. The species of trees of Taxus spp. are in danger of extinction due to logging immoderate, to the low reproduction rate, slow growth; therefore, the plant tissue culture in vitro is a biotechnological alternative high-impact and a great help to the knowledge of the production of the taxoides to level in vitro and above all, for the conservation of this valuable natural resource. The objectives of this article are to determine some general information about the geographical distribution of Taxus spp.; chemical characteristics of taxoids, biological mechanism of action of taxol; path of biosynthesis, methods of extraction and analysis of the taxoids and a current review of the production of taxoids in situ and in vitro cultures and cells of Taxus spp.

Keywords : cancer; biotechnology; secondary metabolism; taxol; Taxaceae.

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