Abstract

ARIZA MARQUEZ, Yeimy Viviana; BELTRAN LOPEZ, Ángela Patricia; BRICENO BALCAZAR, Ignacio  and  ANCIZAR ARISTIZABAL, Fabio. Biological role and applications of miRNAs in breast cancer. Rev. colomb. biotecnol [online]. 2014, vol.16, n.1, pp.188-202. ISSN 0123-3475.  https://doi.org/10.15446/rev.colomb.biote.v16n1.44287.

MiRNAs are small RNAs that are involved in various processes of gene regulation by RNAi and play a key role in various biological, such as cell proliferation, differentiation and apoptosis processes. Consequently, the altered expression of miRNAs contribute to human disease, including cancer. In this review, we will focus on the recent findings of miRNAs that affect the development of cancer, particularly breast cancer, simultaneously evaluate their regulatory mechanisms , their classification , their use as markers of tumor invasion, drug susceptibility and further explore the utility of miRNAs in the diagnosis, monitoring and individualize treatment. Finally found that miRNAs represent a great alternative for understanding the molecular basis of implicit tumor processes in breast cancer and once all targets are known, it will be possible to elucidate at least in part this complex and multigenic process, aided by tools such as generation of databases, to report the differential expression of miRNAs, elements that allow us to preventive medicine and improve the quality of life of patients and their families.

Keywords : breast cancer; miRNAs; anti-oncomir; Oncomir; post-transcriptional regulation; RNAm.

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