Abstract

CATANO, Juan Carlos  and  CASTANO, Omar. Evaluation of the impact of a program of epidemiological surveillance in consumption of antibiotics and flora in a third level clinic. Infect. [online]. 2009, vol.13, n.1, pp.6-13. ISSN 0123-9392.

Objective: To determine the impact of an epidemiological surveillance program in the formulation patterns of antimicrobials, and the frequency of multirresistant bacteria isolated in a third level clinic in Medellin. Materials and methods: A retrospective and observational study, divided in a pre-intervention phase of 18 months, between July 1st 2004 a December 31st 2005, and an intervention phase of 18 months, between January 1st 2006 and June 30th 2007 was carried out. The study was done at Las Vegas Clinic in Medellín on the multiresistant bacteria isolated and the amount of antibiotic prescribed. The observed changes were evaluated in the magnitude of antibiotics formulation (daily defined doses x 100 day-bed) and the changes in the frequency of isolations of multiresistant bacteria. Results: A progressive increase in the use of antibiotics was found without modifying clinic occupation indicators, the intervention policy demonstrated statistically significant reduction in the use of Ceftriaxone (p < 0.001), Imipenem (p 0.01), Meropenem (p < 0.001) and glicopeptides (p 0.04), this was associated with an increase in the Ampicillin/Sulbactam, Piperacillin/Tazobactam, quinolones and aminoglicosides formulation. It did not modify the frequency of evaluated multiresistant germs (p 0.51). Conclusions: An epidemiologic surveillance policy has a positive impact in antibiotic consumption, but this study does not demonstrate a positive impact in multiresistant bacteria isolation frequency.

Keywords : bacteria; resistance; antibacterial agents; surveillance; isolation; epidemiologic.

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