Abstract

ANGEL-SOLARTE, Ingrid Johana et al. Epigenetics and healthy lifestyles of Peripheral Arterial Disease. Entramado [online]. 2022, vol.18, n.1, e217.  Epub June 13, 2022. ISSN 1900-3803.  https://doi.org/10.18041/1900-3803/entramado.1.7289.

Peripheral Arterial Disease (PAD) is characterized by the progressive occlusion of the arteries of the lower extremities, affecting a large part of the world population. It is known that the most recognized risk factors for disease and lifestyle can produce epigenetic changes that influence the development of PAD. Therefore, the purpose of this study was to demonstrate the relationship between epigenetics and lifestyle, associated with PAD, based on a review. The search was carried out in the databases of PubMed, Cochrane, Science Direct, and Google Scholar, choosing only articles in Spanish and English published in the last I0 years. It was found that those people with healthy behaviors such as physical activity good nutrition, and quitting smoking, induce epigenetic changes such as miRNA expression and DNA methylation and histone modification, processes involved in the development and progression of PAD. Epigenetics envisions the need for new strategies that lead to the prevention, treatment, and self-care of healthy behaviors to improve people's quality of life and reduce the burden of this disease.

Keywords : Peripheral Arterial Disease; epigenetics; lifestyles.

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