Services on Demand
Journal
Article
Indicators
Cited by SciELO
Access statistics
Related links
Cited by Google
Similars in SciELO
Similars in Google
Share
Revista Colombiana de Reumatología
Print version ISSN 0121-8123
Abstract
PINTO P, Luis Fernando; VELASQUEZ F, Carlos Jaime and MARQUEZ H, Javier. Subgrupos de Lupus Eritematoso Sistémico: influencia de la edad de inicio, la raza, el sexo y el perfil de anticuerpos en las manifestaciones clínicas de la enfermedad. Rev.Colomb.Reumatol. [online]. 2008, vol.15, n.4, pp.291-298. ISSN 0121-8123.
Systemic Lupus Erythematosus (SLE) is a heterogeneus disease; clinical, serologic and epidemiologic subsets are determinated by age, race and genetic factors. Male lupus patiens have a worst prognosis with more lupus nephritis and disease activity; African-American male have an early severe compromise with lupus nephritis (LN) pleuritis and cytopenias. In children SLE has more lupus nephritis, lymph node enlargement and splenomegaly. In older than 50 years at diagnosis SLE has accrual damage and cardiovascular disease. Antibodies are predictive of clinical subsets; anti-DNA is associated with LN and SLE activity; Anti-Ro is asociated with neonatal lupus syndrome, fotosensitivity and late onset SLE; Antiphospholipid antibodies are predictive of organ damage in SLE.
Keywords : systemic lupus erythematosus; subsets; nephritis; race; sex; age; autoantibodies.