Abstract

GOMEZ-PUERTA, José A. Gout: New pathogenic concepts and new therapeutic agents. Rev.Colomb.Reumatol. [online]. 2011, vol.18, n.3, pp.163-174. ISSN 0121-8123.

Gout is an inflammatory arthritis characterized by selflimiting but excruciatingly painful acute attacks. These are a consequence of monosodium urate crystal deposition within articular or periarticular tissue. After years of acute intermittent gout, chronic tophaceous gout can develop. Gout is the most frequent cause of inflammatory arthritis in men and postmenopausic women. Several important advances had been developed during last years in terms of pathogenic mechanisms, including genetic and inflammatory aspects such as the participation of inflammosome. In that sense, the gout can follow a course similar than othe autoinflammatory disorders. Additionally, new therapeutic agents had been developed, including anti-IL1 antibodies (anakinra, rinolacept and canakinumab) and xanthine oxidase inhibitors such as febuxostat. Those treatments had demonstrated efficacy in term of lowering serum urate concentrations in refractory patients to conventional treatments.

Keywords : gout; hyperuricemia; inflammosome; IL-1; allopurinol; febuxostat.

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