Abstract

SEVERICHE MAURY, David Moisés et al. A series of 115 patients with systemic lupus erythematosus: Clinical and immunological characteristics. Rev.Colomb.Reumatol. [online]. 2014, vol.21, n.4, pp.183-192. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreu.2014.10.002.

Introduction: Systemic lupus erythematosus is an autoimmune disease. The etiology is unknown, and it primarily affects women of reproductive age. Among the most common manifestations are the renal and immune system involvement; the first one is responsible for the majority of the morbidity and mortality of patients, and the second strongly associated with multiple clinical manifestations. Objective: To analyze the prevalence and characteristics of the main clinical and immunological manifestations of 115 patients diagnosed with systemic lupus erythematosus in the Hospital Universitario San Vicente Fundación, and to determine the association between autoantibodies and organ involvement. Materials and methods: Patients were seen by the Rheumatology Group, University of Antioquia, between 2008 and 2012. Clinical and immunological data were collected from the files or electronic medical records using a previously designed format. Results and conclusions: The study found an association between hypocomplementemia and renal involvement, similar to other studies. Nephritis was found in patients with active lupus, as well as a greater impairment of renal function tests such as, creatinine, blood urea nitrogen, creatinine clearance, and proteinuria. The percentage of patients with antidsDNA was 79.1%, and these antibodies were associated with renal involvement, as well as higher Systemic Lupus Erythematosus Disease Activity Index scores; anti-Sm antibodies was associated with serositis and discoid lupus.

Keywords : Lupus nephritis; Autoantibodies; Serositis; Complement C3; Complement C4; Antinuclear antibodies.

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