Abstract

PAULO TRUJILLO, José David  and  MEJIA TURIZO, Juan Carlos. Use of rituximab for granulomatosis with polyangiitis-associated peripheral ulcerative keratitis. Rev.Colomb.Reumatol. [online]. 2017, vol.24, n.1, pp.44-47. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreu.2016.08.003.

A 31-year-old female, presented with polyarthralgia, asymmetrical polyarthritis, fever, vasculitis skin lesions, together with decreased visual acuity in the right eye with severe peripheral corneal melting, peripheral ulcerative keratitis, fibrin hypopyon and posterior synechiae. Given the clinical and paraclinical findings with positive C-ANCA (anti-neutrophil cytoplasmic antibodies), the patient was diagnosed with granulomatosis with polyangiitis with ocular (corneal melting, peripheral ulcerative keratitis and uveitis), and systemic involvement. Treatment was started with methylprednisolone and cyclophosphamide, but due to poor control, Rituximab was subsequently administered, with medical improvement.

Keywords : Granulomatosis with polyangiitis Wegener granulomatosis Cornea Peripheral ulcerative keratitis Rituximab Uveitis.

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