Abstract

QUINTANA, Rosana et al. Accelerated atherosclerosis and cardiovascular disease in systemic lupus erythematosus. Rev.Colomb.Reumatol. [online]. 2021, vol.28, suppl.1, pp.21-30.  Epub Feb 14, 2022. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreu.2021.03.002.

Cardiovascular disease (CVD), particularly coronary heart disease and stroke, is one of the most important causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE). The increased prevalence of CVD and subclinical atherosclerosis, even after adjustment for traditional risk factors, are well established. Several associations with disease-related clinical, genetic and immunological features have been identified. The SLE-specific stratification algorithms with emphasis on composite risk-assessment scores including both traditional risk factors and novel biomarkers is recommended. The clinical complexity of accelerated atherosclerosis will most likely require an integrated approach for the identification, treatment, and intensive study into this aspect of SLE that will ultimately lead to improved cardiovascular outcomes for these patients.

Keywords : Cardiovascular disease; Systemic lupus erythematosus; Accelerated atherosclerosis; Traditional risk factors; Lupus-specific risk factors; Antimalarial recommendations.

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