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CES Medicina
Print version ISSN 0120-8705
Abstract
PINZON-FERNANDEZ, María Virginia et al. Pathogenicity mechanisms and immune response for Chlamydia trachomatis and its relationship with cervical cancer. CES Med. [online]. 2019, vol.33, n.1, pp.51-59. ISSN 0120-8705. https://doi.org/10.21615/cesmedicina.33.1.6.
Cervical cancer is one of the most common worldwide, causing more than 200,000 deaths per year. Progressively, Chlamydia trachomatis has been recognized as a cofactor of cervical carcinoma along Papilloma virus. The interest in this bacterium is related to its asymptomatic nature, the persistence of the infection, the modulation of the immune response of the host and the induction of chronic inflammation and metaplasia.
Objective:
to describe the mechanisms of pathogenicity and immune response against C. trachomatis as cofactors of cervical cancer.
Method:
the literature was reviewed in PubMed / Medline, Lilacs and Redalyc. Articles that referred to the specific topic were selected.
Results and conclusions:
C. trachomatis is a cofactor of cervical cancer. C. trachomatis infection is related to persistence within the cell and its ability to reactivate and reinfect, the property of producing tissue damage, the intensity of the immune response, the ability of the bacteria to modulate immune response and the complexity of these mechanisms that, finally, induce chronic inflammation and cytological alterations. Infection with C. trachomatis confers an increased risk of developing cervical cancer. Diagnosis and timely treatment are necessary to avoid complications that may be related to cervical cancer. It is important to expand the studies that show the findings found.
Keywords : Chlamydia trachomatis; Pathogenicity; Immune response; Cervix carcinoma.
