Abstract

FERNANDEZ TURIZO, María José et al. The role of microRNAs in the pathogenesis of prostate cancer. CES Med. [online]. 2021, vol.35, n.1, pp.26-36.  Epub Oct 26, 2021. ISSN 0120-8705.  https://doi.org/10.21615/cesmedicina.35.1.3.

Prostate cancer is a prevalent disease, with great morbidity and mortality, reported as the fifth leading cause of death worldwide. According to estimates for 2018 by GLOBOCAN (Global Cancer Observatory), 1 276 106 new cases of prostate cancer were reported worldwide. Identifying methods that allow an early diagnosis and treatment of the disease is necessary. MicroRNA are a possible future strategy as biomarkers for prostate cancer. These are small RNA molecules, in charge of regulating genetic expression. Their differential expression is relevant in the pathogenesis of prostate cancer. Currently, literature suggests the differential expression of these biological molecules could be a tool in prostate cancer, with clinical utility. In Colombia new research related to microRNA and prostate cancer is being conducted, which justifies the pertinence of this literature review and the contribution it can have on future research.

Keywords : MicroRNAs; Prostate cancer, Biomarkers, Genetic therapy..

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