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Revista Colombiana de Cancerología
Print version ISSN 0123-9015
Abstract
MEDINA, Diego et al. Haematopoietic stem cell transplantation in paediatric patients with myeloid malignancies; 15 years of experience. rev.colomb.cancerol. [online]. 2018, vol.22, n.2, pp.69-75. ISSN 0123-9015. https://doi.org/10.1016/j.rccan.2018.05.004.
Objective:
To describe the experience, in terms of survival and complications, with patients that received a haematopoietic stem cell transplantation (HSCT) in the last 15 years.
Materials and methods:
A descriptive, retrospective, cohort study was conducted on patients less than 18 years-old with a diagnosis of acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML), and myelodysplastic syndrome (MDS) and received HSCT between January 2001 and December 2015. The outcomes were, overall survival, event-free survival, and complications associated with the transplant.
Results:
During the study period, a total of 43 patients with myeloid neoplasms received a transplant, of which 31 (72%) had AML, 4 (9%) with CML, and 8 (19%) with MDS. A total of 11 identical donor transplants were performed, as well as 11 haploidentical, 11 autologous, and 10 with umbilical cord blood. Of the patients with AML (31 cases), 58% were subjected to a transplant in the first full remission, and 39% in the second or subsequent full remission. The overall and event-free survival at 5 years was 56% and 38%, respectively. The transplant-related mortality at day 100 was 15%, with an accumulated incidence of graft versus host disease of 59%, cytomegalovirus infection of 39%, with 54% bacterial infections, and 14% haemorrhagic cystitis.
Conclusion:
The low mortality and complications rate associated with the transplant suggests that haematopoietic stem cell transplantation is a viable alternative as a treatment for patients with myeloid neoplasms in our country.
Keywords : Haematopoietic stem cell transplantation; Myeloid leukaemia; Myelodysplastic syndrome; Survival; Infection.