Abstract

DE CASTRO, VANESSA; MARTIN-LOPEZ, MERCEDES  and  NAVARRO, JOSÉ FRANCISCO. Effects of LY354740, a Selective Agonist for Glutamate Metabotropic Receptors of Group II, on Aggressive Behaviour in Mice. Univ. Psychol. [online]. 2010, vol.9, n.3, pp.617-625. ISSN 1657-9267.

Recent studies have demonstrated that glutamate metabotropic receptors mGlu1 and mGlu5 are involved in the regulation of aggressive behaviour. This study examines the effect of the administration of LY354740 (4-16 mg/kg i.p.), a selective group II metabotropic receptors agonist (mGlu2/3), using an isolation-induced aggression model. Individually housed mice were exposed to anosmic opponents 30 min after drug administration. Ten min of diadic interactions were staged between a singly housed and an anosmic mouse in a neutral area. The encounters were videotaped and the accumulated time allocated by subjects to ten broad behavioural categories was estimated using an ethologically based analysis. LY354740 (12 and 16 mg/ kg) significantly reduced offensive behaviours, without affecting immobility,as compared with the control group. These results suggest an implication of mGlu group II receptors in the modulation of aggression.

Keywords : Aggression; Agonistic Behaviour; Metabotropic Glutamate Receptors; mGlu2/3; Mice; Receptors; Metabotropic Glutamate; Aggressiveness (Psychology); Rats-Psychology.

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