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Revista Colombiana de Cardiología
Print version ISSN 0120-5633
Abstract
ROJAS-GUALDRON, Diego F. et al. Brain functional connectivity in takotsubo cardiomyopathy patients. A systematic review of magnetic resonance imaging studies. Rev. Colomb. Cardiol. [online]. 2022, vol.29, n.3, pp.325-333. Epub Sep 01, 2022. ISSN 0120-5633. https://doi.org/10.24875/rccar.m22000161.
Background:
Functional neuroimaging studies may aid to our understanding of the pathophysiology of the takotsubo cardiomyopathy.
Objective:
The aim of the study was to review the available evidence of brain functional connectivity in takotsubo cardiomyopathy patients.
Methods:
This was a systematic review. We searched MEDLINE, LILACS, Ovid (Cochrane), Scopus, and Science Direct for studies conducting functional magnetic resonance imaging (fMRI) in takotsubo patients. After reviewing title/abstract and full text, we selected relevant studies, extracted methodological characteristics, and their main findings, and assessed their risk of bias with the Newcastle-Ottawa scale. We present a narrative review.
Results:
We included five case-control studies from 600 registries. The risk of bias was low; comparability was the main issue. Resting-state fMRI findings suggest significant differences for the hippocampus, the Insula, the amygdala, and the para-hippocampal gyrus. Task fMRI findings suggest significant differences for the Insula, the superior occipital gyrus, and the amygdala. Studies were heterogeneous about the laterality and directionality of these differences.
Conclusion:
Brain connectivity alterations involving elements relevant for autonomic control like the Insula and the Amygdala provide evidence in favor of the role of functional networks in the neurocardiology of stress-related cardiomyopathies. However, it is not possible to determine if this role is causal or consequential.
Keywords : Takotsubo cardiomyopathy; Neuropsychiatry; Magnetic resonance imaging; Functional neuroimaging; Systematic review.