Abstract

PATINO-ARBOLEDA, Marcela; NEGRETE-SALCEDO, Alberto  and  OCAMPO-CHAPARRO, José M.. Hypertensive crisis and bradycardia secondary to midodrine intoxication. Rev. Colomb. Cardiol. [online]. 2022, vol.29, n.5, pp.597-600.  Epub Dec 23, 2022. ISSN 0120-5633.  https://doi.org/10.24875/rccar.21000021.

Syncope, defined as a transitory loss of consciousness characterised by its rapid onset, short duration, and spontaneous complete recovery, is secondary to a wide ethiological group, such as the vasovagal origin triggered by an adrenergic discharge or orthostatism. The management of this entity includes both non-pharmacological measures and pharmacological treatment such as the use of midodrine, a peripherally acting alpha receptor agonist, used in the management of orthostatic hypotension, whose use has shown improvement in the symptoms of this condition. We present a clinical case of an 18-year-old woman, with a history of vasovagal syncope under treatment with midodrine and non-pharmacological measures for 6 months, who was admitted to the emergency department of a level IV care center due to an intentional intake of midodrine overdose. Upon admission, a hypertensive crisis with extreme bradycardia, and liver and kidney involvement were documented. Symptom´s management was started with resolution of clinical and paraclinical alterations, and intervention by the mental health team.

Keywords : Drug overdose; Midodrine; Vasovagal syncope.

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