Abstract

VARGAS RUBIO, José Guillermo; CASAS DUARTE, Lorena; REYES GAVILAN, Pablo  and  IRAGORRI CUCALON, Angela María. Affective symptoms in patients with thalamic lesions and their correlation with the thalamocortical connectivity pattern: a systematic review. Acta Neurol Colomb. [online]. 2020, vol.36, n.3, pp.201-209.  Epub Nov 07, 2020. ISSN 0120-8748.  https://doi.org/10.22379/24224022305.

Since the 1970s, the availability of structural neuroimaging (computed tomography and magnetic resonance imaging) and functional neuroimaging (single photon emission computed tomography (SPECT), positron emission tomography (PET), functional magnetic resonance imaging (fMRI)), has opened a new way in the study of the bidirectional relationship between behavioral phenomena and neuronal activity. The introduction of these techniques led to a better understanding of the impact of a brain injury on cortical activity and on the development of psychiatric symptoms. It is difficult to explain affective symptoms as a consequence of a brain structure dysfunction and is important to consider a brain circuit impairment. Many affective disorders have been associated with lesions in thalamolymbic connections, including major depressive disorder, obsessive-compulsive disorder, addiction to psychoactive substances and post-traumatic stress disorder, and the identification of the connectivity tracts can provide new means for effective therapeutic intervention.

Keywords : Saffective symptoms; diffusion tractography; disease; thalamic; magnetic resonance; mood disorder; thalamic nucleus (Mesh).

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