Abstract

ORTIZ, Blair; JIMENEZ, María José  and  CORREA, Luz Norela. Molecular characterization of glioblastoma multiforme in a patient with long survival. Acta Neurol Colomb. [online]. 2021, vol.37, n.1, pp.27-32.  Epub May 06, 2021. ISSN 0120-8748.  https://doi.org/10.22379/24224022359.

Glioblastoma multiforme is a very aggressive central nervous system tumor with a high celular replacement, local infiltration, degradation of the extracellular matrix and resistance to surgery and chemotherapeutical agents. General survival used to be less than 2 years. However, research in the last years has shown the molecular mechanisms underlying behavior and potentially be a therapeutical targets. We show an adult with 20 years old diagnosed with glioblastoma multiforme when he was 13 years, whose treatment involved resective surgery, chemoterapy and ketogenic diet. Genetic characterization was performed and analyzed in the context of the clinical pathway.

Keywords : glioblastoma multiforme; neoplasms, adjuvant chemotherapy; oncogenes; anticonvulsants; diet, ketogenic (MeSH).

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