Introduction:

Migraine and depressive disorder are highly prevalent and disabling pathologies, which present bidirectional relationships of comorbidity. Common risk factors and pathophysiological mechanisms for both diseases have been described in the literature, as well as associations between them and their clinical presentation.

Methods:

This text is a narrative literature review. The bibliographical material was found through different databases specialized in health sciences.

Results:

Some risk factors are associated with both pathologies, and both share pathogenic factors, including functional, structural, genetic, epigenetic, hormonal changes, among others. Several of the preventive treatments that have shown efficacy in the treatment of migraine are medications or measures with an antidepressant effect.

Discussion:

Considering the associations and common factors described in the literature, it becomes evident that in the approach to patients diagnosed with any of these pathologies, it may be beneficial to consider a possible migraine-depression comorbidity.

Conclusion:

It is important to promote the screening of these two patients diagnosed with some, since it can have therapeutic implications and impact on quality of life.

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