Abstract

MALLARINO MIRANDA, Liset Paola et al. ENDOCRINE DISRUPTING EFFECT OF GENISTEIN ON CAENORHABDITIS ELEGANS. Investig. andina [online]. 2020, vol.22, n.41, pp.19-31.  Epub Feb 24, 2021. ISSN 0124-8146.

Genistein is an isoflavone present in soy, which children highly consume as a substitute for breast milk; however, little is known about its effects at the endocrine level. This paper used Caenorhabditis elegans as a model to evaluate the endocrine disrupting effect of genistein through lethality, growth, reproduction, lipid storage, and changes in the expression of stress response genes (hsp-3, sod- 4, and gpx-4). The results indicated that, although genistein did not induce lethality, it did promote reproduction and increased body length, expression of genes related to cellular stress and oxidative stress, and lipid accumulation. In conclusion, genistein produced effects related to endocrine disruption on C. elegans, most likely through oxidative stress mechanisms.

Keywords : Genistein; endocrine disruption; reproduction; growth; lipid deposits; Caenorhabditis elegans.

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