Abstract

LOZANO, Juan Manuel  and  CUCA SUAREZ, Luis Enrique. In vitro antimicrobial properties of secondary metabolites from Peltostigma guatemalense, a Colombian Rutaceae specie, against the Plasmodium falciparum parasite and bacterial strains. Rev. colomb. cienc. quim. farm. [online]. 2008, vol.37, n.2, pp.164-176. ISSN 0034-7418.

With the study of extracts Peltostigma guatemalense, some fraction without purify and isolated metabolites were found antimicrobial activity against Gram-positive bacteria Staphylococcus aureus ATCC 6538 and Enterococcus faecalis ATCC 29212 and Gram-negative Salmonella typhimurium ATCC 14028s and MS 7953 and as antiparasitic activity against Plasmodium falciparum. The metabolites isolated from extracts of ethanol extract of leaves and wood were: seven alkaloids γ-fagarine, anhidroevoxyn, evoxyn, skimmianine, 7-isopenthyloxi-γ-fagarina, kokusaginina and 4-methoxy-1-methyl-2- quinolone one coumarin, escopoletina, one flavonoid, gardenine B, one Lignan, syringaresinol, one terpene, lupeol, one sterol, sitosterol and two derivatives of benzoic acid: methyl-p-hydroxybenzoate, phenylacetic acid which were identified by spectroscopic methods and by comparison with the data reported in the literature. The alkaloid compounds, anhidroevoxyn, kokusaginine and 4- methoxy-1-methyl-2-quinolone, showed a strong anti Plasmodium activity and the compound p-hydroxybenzoate presented the most promising antimicrobial activity compared with the other compound tested.

Keywords : Peltostigma guatemalense; Rutaceae; alkaloid; flavonoid; anti Plasmodium falciparum activity; antibacterial activity.

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