Abstract

RUIDIAZ, Miller A; DELGADO, Daniel R  and  MARTINEZ, Fleming. Correlating the solubility of indomethacin in 1,4-dioxane + water mixtures by means of the Jouyban-Acree model. Rev. colomb. cienc. quim. farm. [online]. 2010, vol.39, n.2, pp.211-226. ISSN 0034-7418.

In this work the validity of the Jouyban-Acree and Yalkowsky-Roseman models is evaluated to correlate the solubility of indomethacin in 1,4-dioxane + water cosol- vent mixtures. The solubility correlation is studied as a function of temperature and cosolvent composition. Both models require only the experimental solubility values in the pure solvents at all the temperatures evaluated. The solubility calculated values by using both models deviate notoriously from experimental values in several cases

Keywords : indomethacin; 1,4-dioxane + water mixtures; Jouyban-Acree and Yalkowsky-Roseman models.

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