Abstract

BALUJA, Shipra; KULSHRESTHA, Anchal  and  MOVALIA, Jagdish. 1-Octanol-water partition coefficient of some cyanopyridine and chalcone compounds. Rev. colomb. cienc. quim. farm. [online]. 2017, vol.46, n.3, pp.342-356. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v46n3.69466.

The partition coefficients (P) of some synthesized cyanopyridine and chalcone compounds have been studied in 1-octanol-water system at different pH. It is observed that log P depends on pH and nature of substitution group present in the compounds. The central moiety also play important role to affect hydrophilic/ hydrophobic nature of compounds. There is no regular trend for the variation of log P with different pH.

Keywords : partition coefficient; cyanopyridines; chalcones; 1-octanol-water system.

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