Abstract

DA SILVA MENOLLI, Poliana Vieira; GOULARTE GARSO, Pedro Augusto; MOLINO GUIDONI, Camilo  and  GIROTTO, Edmarlon. Antidepressive use and self-rated health among adults of 40 years and older: longitudinal study. Rev. colomb. cienc. quim. farm. [online]. 2020, vol.49, n.1, pp.183-198.  Epub Nov 10, 2020. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v49n1.85776.

Antidepressants are one of the fastest growing classes of prescription drugs in the world and their effects on users' quality of life are still controversial. The aim of the study was verify the relationship between antidepressant use and self-rated health in a population aged 40 years or older. This was a population-based longitudinal study with adults of 40 years or older in a medium-sized municipality in Brazil with data collection in 2011 and 2015. The dependent variable was self-rated health (2015) and the independent the use of antidepressant medications, categorized as "used only in 2011", "used only in 2015", "used in 2011 and 2015" and "not used". The Poisson regression with robust variance was used to verify the association between antidepressant use and self-rated health. The study included 885 people. Negative self-rated health was present in 44% of the study population. The prevalence of antidepressant use was 17.6% over 4 years. The use of antidepressants was associated with negative self-rated health for individuals who were only using 2015 in the general population (PR 1.082; 95% CI 1.004-1.166). There was no relationship between antidepressant use and self-rated health, except for those who used antidepressants only in 2015.

Keywords : Antidepressants; self-rated health; longitudinal study.

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