Abstract

CARDENAS, Rossember E. et al. Prediction of sulfadiazine solubility in some cosolvent mixtures using non-ideal solution models. Rev. colomb. cienc. quim. farm. [online]. 2020, vol.49, n.3, pp.822-842.  Epub Feb 25, 2021. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v49n3.91347.

The experimental data of sulfadiazine in (methanol + water), (ethanol + water) and (1-propanol + water) cosolvent mixtures at some temperatures were correlated using non-ideal solution models, namely, the modified Apelblat and Buchowski-Ksiazaczak equations and the van't Hoff equation. The calculated results agreed well with the experimental data. According to the Buchowski equation, the solubility of sulfadiazine in the three co-solvent mixtures shows important deviations from ideality, which is consistent with the literature.

Keywords : Sulfadiazine; solubility; van't Hoff model; Buchowski-Ksiazaczak 2h model; Apelblat model.

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