Abstract

VIVAS, Carlos Arturo et al. Hypothyroidism and risk of miscarriage. Rev Colomb Obstet Ginecol [online]. 2009, vol.60, n.2, pp.179-187. ISSN 0034-7434.

Objective: this article was aimed at searching the literature for an association between hypothyroidism and miscarriage. Methods: a search was made on the Medline electronic database, using Pubmed and Ovid for identifying relevant material. Results: some studies showed an increased risk of miscarriage in patients suffering from overt hypothyroidism and subclinical hypothyroidism, and in euthyroid patients having antithyroid antibodies; a strong association was seen in the latter group. Early diagnosis and treatment of pregnant women having subclinical, overt hypothyroidism and the search for antithyroid antibodies is highly recommended in recurrent miscarriage. Despite some studies having shown a decrease in the risk of miscarriage when levothyroxine treatment was used with patients having antithyroid antibodies, it cannot be recommended yet. Conclusion: more studies using an increased number of patients have to be carried out to define a true association between miscarriage and thyroid disorders and thus establish suitable treatment.

Keywords : pregnancy; hypothyroidism; subclinical hypothyroidism; miscarriage; autoimmunity; thyroid auto antibodies; thyroiditis; thyroxine.

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