Abstract

GRUBMAN, Marvin J. New approaches to control foot-and-mouth disease: antivirals and novel vaccines. Rev Colom Cienc Pecua [online]. 2006, vol.19, n.3, pp.341-346. ISSN 0120-0690.

Foot and mouth disease (FMD) is a highly contagious viral-induced disease of cloven-hoofed animals that results in serious economic consequences in affected countries that have a significant international livestock trade. Currently disease control measures include inhibition of susceptible animal movement, slaughter of infected and susceptible in-contact animals, disinfection, and possibly vaccination with an inactivated whole virus antigen. However, there are a number of problems with use of the current vaccine in outbreaks in countries which have been previously free of FMD. As a result countries which vaccinate face a longer delay in regaining FMD-free status than countries which do not vaccinate but rather slaughter all infected or susceptible in-contact animals. Researchers have been attempting to develop both new FMD vaccines to overcome the limitations of the current inactivated vaccine as well as methods to more rapidly induce a protective response. In this manuscript I discuss the most effective new FMD vaccines and novel antiviral strategies that are currently being examined.

Keywords : antiviral strategies; foot and mouth disease; prevention, vaccines.

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