Abstract

OLIVERA A, Martha; TARAZONA M, Ariel; RUIZ C, Tatiana  and  GIRALDO E, Carlos. Bovine luteolysis: intracellular signals. Rev Colom Cienc Pecua [online]. 2007, vol.20, n.3, pp.387-393. ISSN 0120-0690.

The corpus luteum is a transient gland that produces progesterone during a period of time that is determined by the length of gestation. When there is no gestation the corpus luteum undergoes regression, a process commonly known as luteolysis. This process has been divided in: functional, since there is a lost of the capacity to synthesize progesterone; and structural, because there is a disruption of the cellular structure. PGF_2α, is the principal luteolytic factor, but there are other parallel pathway mediated by calcium, cytokines, reactive oxygen species and endothelins. All these routes end up in inhibition of steroidogenesis and/or apoptosis. In this article we try to integrate the information present in the literature and propose a map depicting the major cellular and molecular events taking place in this process that is fundamental en bovine reproduction.

Keywords : apoptosis; oxitocin; PGF_2α; steroidogenesis inhibition.

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