Abstract

PISCIOTTI, Iván et al. Factors associated with the development of adverse events with fresh frozen plasma transfusion. Acta Med Colomb [online]. 2013, vol.38, n.3, pp.127-131. ISSN 0120-2448.

Abstract Place: Fundación Cardio-infantil (FCI), Bogotá, Colombia. Objective: to determine factors associated with transfusion-associated adverse events with fresh frozen plasma (FFP) in the FCI during the years 2008-2010. Methodology: case-control study, in ratio 1:3. Patients over 18 years transfused with FFP in the FCI during the years 2008-2010. Cases were identified from the FCI transfusion -associated adverse events registry. Controls received FFP transfusion and had no adverse events. Results: the average age of cases was lower than that of controls (52.4 vs. 60.5 years, p = 0.001). The adverse events were the most frequent ones, and increased with the use of units from other blood banks (0.7 vs. 0.0 units, p = 0.003), when the donor was female (2.5 vs. 1.4 female donors, p = 0.11) and with the increased parity of such donors (4.0 vs. 2.6 deliveries, p = 0.04). Sepsis (or: 0.1, 95% Ci:0,01-0, 87, p = 0.015) and diabetes (or: 0.9, 95% Ci:0,01-0, 54, p = 0.003) behaved as protective factors for the development of adverse allergic type events. Conclusions: the transfusion-associated adverse events with PFC are associated with female multiparous donors and with blood units provided by non-institutional blood banks. Its incidence could diminish by not allowing female donors with more than four pregnancies. (Acta Med Colomb 2013; 38: 127-131).

Keywords : fresh frozen plasma transfusion; adverse event.

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