Abstract

GONZALEZ-GARCIA, Mauricio et al. Survival of patients with idiopathic pulmonary fibrosis at the altitude of Bogota (2640 m). Acta Med Colomb [online]. 2014, vol.39, n.1, pp.15-20. ISSN 0120-2448.

Abstract Introduction: the mean survival of patients with idiopathic pulmonary fibrosis (IPF) at sea level is two to three years. We don't know its behavior in Bogotá, a city at high altitude (2640 meters), where there is greater hypoxemia, factor associated in the literature with poor prognosis. The objective of the study is to describe, in a cohort of patients with IPF survival and clinical and functional characteristics at the time of diagnosis. Methods: patients diagnosed with IPF confirmed by biopsy or by clinical, radiological and functional criteria. Survival analysis of Kaplan Meier and log rank test was utilized. Results: forty patients , 50% women with age 59.1 ± 13 years. 52.5% had biopsy . At diagnosis, PaO2: 48.5 ± 11.2 mmHg, FVC: 61.5 ± 16.8%, CPT: 66.1 ± 11.7%, DLCO: 39.5 ± 12.4%. Survival from diagnosis was 42 months (95% CI 25.3-58.7 months) and from the onset of symptoms 50 months (95% CI 40.3-59.7 months). There was no difference in survival by sex, smoking history, form of diagnosis (biopsy or not biopsy), blood gas and pulmonary function variables. There was a lower survival in patients older than 60 years (23 vs. 72 months, p = 0.03). Conclusions: the survival of patients with IPF in Bogota with significant hypoxemia at diagnosis was similar to that described in studies at sea level. Age older than 60 years was associated with poor prognosis. (Acta Med Colomb 2014; 39: 15-20).

Keywords : idiopathic pulmonary fibrosis; survival; altitude.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )