Abstract

BONILLA, Diego A  and  MORENO, Yurany. Molecular and metabolic insights of creatine supplementation on resistance training. Rev.Colomb.Quim. [online]. 2015, vol.44, n.1, pp.11-18. ISSN 0120-2804.  https://doi.org/10.15446/rev.colomb.quim.v44n1.53978.

In recent years the research problem in the field of sports supplementation has changed to explain the metabolic mechanisms by which creatine (Cr) administration enhances the performance of certain sports or simply benefits the muscular adaptation. In this review for first time the biochemical mechanisms of Cr ingestion in a cell signaling insight were analyzed, focusing on energetic bioavailability enhancement and optimization of the temporal and spatial buffering of Cr/PCr/CK system. Moreover, intensification in proliferation and differentiation processes of muscle cells (IGF-I/PI3K/Akt-PKB, SPHK1/MAPK/p38/MRFs, mTOR, cellular swelling, mitotic activity of satellite cells, actin polymerization, and myoblast fusion) and inactivation and/or reduction in the expression of ergolitic metabolites (GSK3β, myostatin and AMPK regulation) were examined. In this way, we explained from a metabolic point of view the increase in muscle mass, strength, fatigue resistance, and performance of high intensity sports after Cr monohydrate supplementation.

Keywords : Cr/PCr/CK System; creatine monohydrate; muscle energy metabolism; MAPK; IGF-I; resistance training; high-intensity exercise.

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