Abstract

TAFUR-BETANCOURT, Luis Alberto. The hidden world of drug interactions in anesthesia. Rev. colomb. anestesiol. [online]. 2017, vol.45, n.3, pp.216-223. ISSN 0120-3347.

Drug interactions represent the cornerstone in the basic anesthetic triangle and knowledge about such interactions contributes to a solid foundation for administering medications.

This article dwells on the anesthetic drug interactions: pharmaceutical (mixing or not mixing), pharmacokinetic (alterations in distribution, metabolism, or clearance), pharmacodynamics (synergism, additive effect) and thermodynamic (affinity and intrinsic activity).

The basic anesthetic triangle is a current concept and drug interactions are the cornerstone for safe anesthesia. These interactions are currently neglected and hence the anesthetist should recognize any drug interactions for a safer practice of anesthesia.

Keywords : Pharmacology; Drug Interactions; Chemistry; pharmaceutical; Pharmacokinetics; Anesthesia.

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