Abstract

ANDRADE, Jenny Patricia et al. Preformulation study for the development of a polymer-based gel with mucoadhesive propierties for its use in allelopathy assays in marine invertebrates. Acta biol.Colomb. [online]. 2010, vol.15, n.1, pp.87-104. ISSN 0120-548X.

This study was carried out with the purpose of implementing a methodology to assess allelopathic interactions assays between corals and reef sponges reducing the physical interaction caused by the use of devices that involve abrasion and harm over the coral polyps. Was carried out a preformulation study using polymers with mucoadhesive on the mucus that cover the coral polyps, with the purpose of develop a gel, incorporating an extract from Cliona Delitrix into the formulations. Obtained formulations were characterized by properties such as extensibility, adherence and mucoadhesive capacity. These formulations showed great physical stability under prevalent marine conditions both in vitro and in situ. In the same way was designed a device that let the smearing of the gel over the coral surfaces carried out for the divers in the coral reefs. Finally, was studied the releasing behavior of the gel with the sponge´s extract into the sea water conditions

Keywords : mucoadhesive polymers; mucoadhesion; preformulation; gel; marine chemical ecology; allelopathy; sponges,corals.

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