Abstract

RIVAS G, ANA MARÍA  and  CARDONA-CASTRO, NORA. Systemic antifungals: which therapeutic options do we have?. CES Med. [online]. 2009, vol.23, n.1, pp.61-76. ISSN 0120-8705.

The prevalence of invasive fungal infections has increased over the past three decades owing to the increasing numbers of immunocompromised hosts. For many years, amphotericin B and flucytosine were the only available antifungal agents for invasive fungal infections. Fortunately, the antifungal drugs has increased, providing new therapeutic options for these patients. The purpose of this article is to summarize the pharmacologic profile of traditional antifungal drugs (amphotericin, flucytosine, itraconazole, fluconazole) as well as the ones recently licensed: the new triazoles (voriconazole, posaconazole) and the echinocandins (caspofungin, micafungin, anidulafungin).

Keywords : Antifungal agents; Amphotericin B; Flucytosine; Azoles; Echinocandins.

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