Abstract

GONZALEZ TRUJILLO, Fernando et al. Glioma type pilocytic astrocytoma "atypical recurrent" and gen BRAF:Clinical case presentation, discussion. Acta Neurol Colomb. [online]. 2017, vol.33, n.2, pp.119-126. ISSN 0120-8748.  https://doi.org/10.22379/24224022143.

The pilocytic astrocytoma (PA), formerly referred to as juvenile pilocytic astrocytomas, are WHO grade I tumors, that commonly occur during childhood and rarely in the adult population. Genetic studies of this tumor report an activation of the MAPK / ERK pathway through changes in the BRAF gene.

The aim of this article is to report a series of atypical PA cases with an aggressive tumor biology that continue preserving the benign histology or transformed into high-grade gliomas, and review the biology, genetics, and emerging therapeutic possibilities for these cases. And finally expose controversies from the surgical treatment and complementary therapies.

Keywords : Gliomas; gene; mutation; deletion; atypical; (MeSH).

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )