Abstract

URREGO DIAZ, José Augusto; OTERO REGINO, William  and  GOMEZ ZULETA, Martín. Helicobacter pylori and hematologic diseases. Rev Col Gastroenterol [online]. 2013, vol.28, n.4, pp.329-337. ISSN 0120-9957.

Helicobacter pylori are Gram negative spiral bacteria that colonize human gastric epithelia. Their association with many gastric diseases, including roles in the pathogenesis of chronic gastritis, peptic ulcers, dyspepsia, MALT and gastric cancer is well known. In addition increasing amounts of evidence indicate that they are associated various extragastric entities such as colon cancer, neurodegenerative diseases, liver diseases, coronary artery disease, hematologic diseases and others. Of these, three hematologic diseases have clear associations with strong evidence: iron deficiency anemia when there is no other explanation, Vitamin B12 (cobalamin) deficiency and immune thrombocytopenic purpura. Many pathogenic mechanisms have been proposed for these three disorders, and there are many studies that support these associations. In this article we review the role of Helicobacter pylori and its pathogenetic mechanisms in the development of these three hematologic diseases

Keywords : Helicobacter; purpura; anemia; iron.

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