Abstract

VELEZ M, Jhonathan Ferney; CRESPO H, Gustavo Amador  and  RESTREPO G, Juan Carlos. Vitamin E Treatment for Patients with Nonalcoholic Steatohepatitis. Rev Col Gastroenterol [online]. 2014, vol.29, n.4, pp.397-403. ISSN 0120-9957.

Nonalcoholic Steatohepatitis (NASH) is characterized histologically by the ballooning of hepatocytes, lobular inflammation and steatosis. If this diagnosis is suspected, it is important to exclude other causes of liver damage, especially excessive consumption of alcohol. Nevertheless, to date, a biopsy is the only method available to confirm the diagnosis. Vitamin E should be considered a first-line therapy for treatment of this disease because several clinical studies have shown that a dose of 800 UI/day improves the histology of non-diabetic adults suffering from NASH even when there is no significant impact on fibrosis. These results were confirmed by biopsies. Despite the proven benefits of the use of this drug, it is important to be aware that its use cannot replace changes in diet and exercise but rather should be seen as a complement to these measures

Keywords : Nonalcoholic steatohepatitis; vitamin E; oxidative stress.

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