Abstract

BARRERA-ESCOBAR, Sebastián; HURTADO-GONZALEZ, Manuela; VANEGAS-RAMIREZ, Gustavo  and  VILLA-FRANCO, Juan Pablo. Mid-line destructive syndrome secondary to infection by paracoccidioides sp. A case report. Iatreia [online]. 2022, vol.35, n.3, pp.361-367.  Epub May 19, 2023. ISSN 0121-0793.  https://doi.org/10.17533/udea.iatreia.160.

Midline destructive disease is a group of severe and destructive inflammatory and tumor diseases of the midface area, among which paracoccidioidomycosis is one of the main etiologies in tropical countries.

Paracoccidioidomycosis is an endemic mycosis caused by fungi of the genus Paracoccidioides. Its blastoconidia form favors hematogenous spread, affecting various tissues such as adrenal glands, reticulo-endothelial tissue, or oral mucosa, where it can manifest as a destructive midline syndrome. We present a case of paracoccidioidomycosis with affection in the oral cavity, which debuted as a chronic midline destructive disease with sever airway compromise that required surgical treatment for the risk of obstruction of the airway. The patient received systemic treatment with good response.

Keywords : Invasive Fungal Diseases; Mycoses; Paracoccidioidomycosis.

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