Abstract

BELTRAN, ORIETTA. MEDICAL APPLICATIONS OF INDUCED PLURIPOTENT CELLS SPECIFIC-PATIENT. rev.fac.med [online]. 2013, vol.21, n.1, pp.91-101. ISSN 0121-5256.

Recent advances in the implementation of strategies of genetic reprogramming somatic cells to produce induced pluripotent cells (iPS), open the possibility of generating pluripotent cells for studies of embryonic development and cell differentiation, tools for in vitro detection of new drugs and evaluation of their efficacy and toxicity, in order to develop in vitro models of human disease and use in cell therapy. iPS cells are showing phenotypic and functional characteristics similar to those seen in embryonic stem cells, without the ethical and legal questionings of the experimental manipulation of embryos. In particular, generation of patient-specific pluripotent stem cells elucidate the pathophysiological processes of various genetic diseases of known and unknown aetiology, and raises the possibility of autologous cell therapy and cell-based gene therapy for tissue regeneration depending individual needs.

Keywords : Disease modeling; cell therapy; patient-specific pluripotent stem cells; cell reprogramming.

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