Abstract

SACRISTAN RODRIGUEZ, Paola Andrea; SANCHEZ GUTIERREZ, Sandra Milena  and  BONILLA CORTES, Leonardo. Refractory Primary Immune Thrombocytopenia in Pregnancy A Case of Study A Case of Study. Rev. Med [online]. 2021, vol.29, n.1, pp.105-109.  Epub Dec 31, 2021. ISSN 0121-5256.  https://doi.org/10.18359/rmed.5393.

primary immune thrombocytopenia (PIT) is a common autoimmune disorder that varies with patients of all ages, genders, and races. The diagnosis excludes all those thrombocytopenias due to other autoimmune diseases, infections, or drugs so that no alteration is evident in the remaining cell lines. More than 80 % of autoimmune thrombocytopenias respond favorably to first-line treatments and, the remaining 20 %, up to 60 % will resolve with second-line treatments. Only 3 % to 8 % will not respond to conventional management, thus setting up refractory immune thrombocytopenia, therefore becoming a therapeutic challenge. The incidence of refractory immune thrombocytopenia is unknown during pregnancy and is limited to the reports of a few cases in the literature. We present the case of a pregnant woman with a history of PIT that became refractory during pregnancy with persistently low platelet counts, bleeding symptoms and therapeutic limitations due to her pregnant condition.

Keywords : thrombocytopenia; pregnancy; hematological complications of pregnancy; high-risk pregnancy.

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