Abstract

DE SIMONE, Emilio et al. Alendronate effects on cytokines and metalloproteases 2 and 9 profiles in an experimental arthritis murine model. Rev.Colomb.Reumatol. [online]. 2013, vol.20, n.4, pp.202-210. ISSN 0121-8123.

Abstract Introduction: Arthritis is one of the most common arthropathies, characterized by cartilage damage associated with subchondral bone resorption. Early diagnosis is crucial for the prevention of subchondral bone lesions. Objectives: To use an experimental adjuvant arthritis rat model, to measure joint biomarkers, interleukins (IL-4, IL-6 and TNF-a), and metalloproteases (MMP-2 and MMP-9) to follow the progression of the disease and to analyze the possible changes in the different treatment groups, with preventive or curative alendronate. Materials and methods: Preventive alendronate was applied on day 0, and a curative regimen 2 months post-adjuvant. A clinical scale score was used for characterizing clinical symptoms, and, at sacrifice, joint biomarkers and histopathological and radiographic studies were determined. Results: The most notable result was that the group that received preventive alendronate reached a normal clinical score faster than control adjuvant group. All alendronate groups showed significantly lower MMPs levels. Conclusions: Alendronate apparently decreases proteases activity linked to the pathophysiology of joint disease, this could be extremely beneficial for the clinical outcome of arthritis.

Keywords : Alendronate; Arthritis; Metalloproteases; Interleukins.

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