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Revista Colombiana de Reumatología
Print version ISSN 0121-8123
Abstract
LOPEZ, Pilar Pérez; MOSQUERA PONGUTA, Catalina and GUTIERREZ, Clara Malagón. Prevalence of kidney involvement during the first year of follow-up in patients with Henoch-Schönlein purpura in a paediatric institution in Bogotá, Colombia. Rev.Colomb.Reumatol. [online]. 2017, vol.24, n.2, pp.63-69. ISSN 0121-8123. https://doi.org/10.1016/j.rcreu.2017.02.002..
Introduction:
Henoch-Schönlein Purpura is the most common vasculitis in children, with Henoch-Schönlein Purpura kidney involvement remaining the main cause of morbidity and mortality. The spectrum of Kidney involvement of kidney involvement ranges from mild symptoms to the development of a nephrotic and/or nephritic syndrome or kidney failure.
Objective:
To determine the clinic features at onset, and kidney involvement of patients with a final diagnosis of Henoch-Schönlein Purpura during the first month, 3 months, and up to the first year of follow-up.
Methods:
A retrospective study conducted on patients with a final diagnosis of Henoch-Schönlein Purpura in a Paediatric Rheumatology Department in an institution of Bogota, Colombia, during the period between 2010 and 2016.
Results:
The study included 86 patients, 42 girls and 44 boys. The median age at disease onset was 5.3 years (SD 2.4 years: range1-14years). Kidney involvement was present in 39/86 (45%) patients. A trend to kidney involvement was observed in patients with abdominal symptoms (p=,053). The most frequent clinical finding was isolated proteinuria (49%), followed of proteinuria/haematuria (28%), and isolated hematuria (15%). Renal biopsy was performed on 8/39 patients with Henoch-Schönlein Purpura nephritis. The mean follow-up was 26.8 months (SD 17 months: range 1-72). There was no evidence of kidney damage in the last assessment in any of the 39 patients with kidney involvement.
Conclusion:
In this group of patients, kidney involvement was more severe and common in the first weeks of the disease onset.
Keywords : Henoch-Schönlein Purpura; Kidney involvement; Renal biopsy.