Abstract

TRILLERAS, Jorge; DE-LA-ROTTA, Freddy-Ríos  and  PEDROZA-GARCIA, Luis-Felipe. Ultrasound-Assisted Synthesis of Fused Polycyclic pyrazolo[3,4-b]pyridines. Rev. Cient. [online]. 2023, n.47, pp.1-12.  Epub Sep 20, 2023. ISSN 0124-2253.  https://doi.org/10.14483/23448350.19651.

This work describes a synthetic methodology developed to obtain fused polycyclic pyrazolo[3,4-b]pyridines. The synthesis was carried out in two stages, starting with the preparation of α,β-unsaturated naphthones and their subsequent cyclocondensation with 5-amino-1-phenyl-3-methyl-1H-pyrazole. The advantages of this approach include simplicity, atomic efficiency, selectivity, and good yields with minimal environmental impact. The synthetic route is aimed at obtaining N-heterocycles with specific points of structural diversification that are of interest for later exploration of their biological properties.

Keywords : 5-aminopyrazole; cyclocondensation; fused pyrazole derivatives; pyrazolo[3,4-b]pyridine; ultrasound synthesis..

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