Abstract

BELTRAN CIFUENTES, Martha Cecilia; DURAN OSPINA, Patricia  and  CORREDOR ARIAS, Luisa Fernanda. AMOLECULAR BIOLOGY LEISHMANIA SPP NEW DRUGS RESISTANCE. Investig. andina [online]. 2008, vol.10, n.16, pp.81-91. ISSN 0124-8146.

Introduction: In Colombia there are research groups in Leishmaniasis that have joined forces to achieve the identification of the genome of Leishmania spp. As health professionals know this is a priority to understand the mechanisms of drug resistance. Methods: The databases used for this search were among others: NCBI PubMed MEDLINE, Science Direct, Nucleic Acids Research and Biochemical and Molecular Parasitology, as a publication of the journal Biomedical and several universities. Results: There are many species and vectors distributed throughout the country. The multiresistents created by Leishmania spp. rely especially in membrane proteins and mutations in the DNA of the parasite and their delivery systems. Conclusions: The PCR techniques should be implemented at the clinic to study resistance to drugs. The current protocols against Leishmaniasis not include additional alternatives. The treatments with immunomodulators are the new hope for treating this re-emerging disease.

Keywords : Leishmania spp; drug resistance; molecular biology.

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