Abstract

RODRIGUEZ, Javier et al. CARACTERIZACIÓN TEÓRICA DE PÉPTIDOS DE ALTA UNIÓN DE EBA-181 MEDIANTE LA APLICACIÓN DE LA TEORÍA DE LA PROBABILIDAD Y LA ENTROPÍA. Rev. acad. colomb. cienc. exact. fis. nat. [online]. 2012, vol.36, n.141, pp.535-543. ISSN 0370-3908.

EBA-181, antigen of Plasmodium falciparum, binds to red blood cells, suggesting a role in the merozoite invasion. It was applied a previously developed methodology based on probability and entropy, to the characterization of high-binding EBA-181 peptides to red blood cells. Values of probability, probability summation and entropy were calculated for the 79 not overlapped sequences of the protein; the calculations were also made for analogous theoretical peptides, built from the binding peptides. The specific sequences experimentally proved as high binding ones had values into the ranges associated to the binding macrostate, differentiating the sequences that bind and not bind with a right guess of 100% in the studied cases.

Keywords : Probability; Entropy; High binding; EBA-181; erythrocyte; merozoite.

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