Abstract

BALDIRIS-AVILA, Rosa; ACOSTA-TAPIA, Natali; ARZUZA-ROMERO, Andrea  and  VIVAS-REYES, Ricardo. Network of protein-protein interaction of phosphatidylinositol 4, 5-bisphosphate 5-phosphatase, related with Lowe syndrome. Rev. acad. colomb. cienc. exact. fis. nat. [online]. 2016, vol.40, n.157, pp.559-567. ISSN 0370-3908.  https://doi.org/10.18257/raccefyn.381.

Lowe syndrome is a disease transmitted by sex-linked inheritance. That mainly affects males, and very occasionally women. It consists of a mutation in the gene OCRL1 that affects inositol phosphate metabolism, producing significant problems on the eye, nervous system and kidneys. A network of protein-protein interaction for the enzyme phosphatidylinositol 4,5-bisphosphate 5-phosphatase in the Cytoscape software version 3.3.0 was build, from the information provided by the KEGG database, PubMed, BioGrid, STRING, Uniprot data, 26 proteins were extracted related with OCRL. Based on a functional and topological analysis, was obtained ontological categories (GO) of greater significance are related mediated transport vesicles and signal transduction steps by small GTPases. On the other hand, topological parameters of the network were built, transitivity coefficient: 0.033, diameter: 5,0 centralization: 0.55.

Keywords : Lowe syndrome; Cytoscape 3.3.0; OCRL; Bioinformatics; PPIs.

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