Abstract

OSORIO, José Henry. VARIABILITY IN LEVELS OF EXPRESSION AND ACTIVITY OF HUMAN CYTOCHROME P450 2A6 (CYP2A6) AND ITS RELATIONSHIP WITH TOBACCO CONSUMPTION. Biosalud [online]. 2010, vol.9, n.1, pp.36-46. ISSN 1657-9550.

The development of nicotine dependence is determined not only by social factors but also by individual psychological and biological factors. Human cytochrome P450 2A6 (CYP2A6), the enzyme that catalyses the metabolism of nicotine, has been shown to have large interindividual and interethnic variability in expression and activity levels. The interindividual variation in metabolic activity may affect the metabolism of CYP2A6 substrates including nicotine, cotinine (the major metabolite of nicotine), several tobaccospecific procarcinogens, coumarin and many toxins. The present review analyses the scientific literature related to variations in CYP2A6 and tobacco consumption.

Keywords : CYP2A6; nicotine; metabolism; tobacco.

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